Advanced Biomaterials and Biodevices

This cutting-edge book focuses on the emerging area of biomaterials and biodevices that incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities

The design and development of biomaterials play a significant role in the diagnosis, treatment, and prevention of diseases. When used with highly selective and sensitive biomaterials, cutting-edge biodevices can allow the rapid and accurate diagnosis of disease, creating a platform for research and development, especially in the field of treatment for prognosis and detection of diseases in the early stage. This book emphasizes the emerging area of biomaterials and biodevices that incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities.

The 15 comprehensive chapters written by leading experts cover such topics as:

• The use of severe plastic deformation technique to enhance the properties of nanostructured metals
• Descriptions of the different polymers for use in controlled drug release
• Chitin and chitosan as renewable healthcare biopolymers for biomedical applications
• Innovated devices such as “label-free biochips” and polymer MEMS
• Molecular imprinting and nanotechnology
• Prussian Blue biosensing applications
• The evaluation of different types of biosensors in terms of their cost effectiveness, selectivity, and sensitivity
• Stimuli-responsive polypeptide nanocarriers for malignancy therapeutics

Ashutosh Tiwari is an Associate Professor at the Biosensors and Bioelectronics Centre, Linköping University, Sweden; Editor-in-Chief, Advanced Materials Letters; Secretary General, International Association of Advanced Materials; a materials chemist and also a docent in applied physics at Linköping University, Sweden. He has published more than 350 articles, patents, and conference proceedings in the field of materials science and technology and has edited/authored more than fifteen books on the advanced state-of-the-art of materials science. He is a founding member of the Advanced Materials World Congress and the Indian Materials Congress.

Anis N. Nordin received her D.Sc. in computer engineering from George Washington University in 2008. She is now an Assistant Professor in the Department of Electrical and Computer Engineering at the International Islamic University Malaysia, Kuala Lumpur. Her main research interests are in the areas of biosensors, lab-on-chip devices, Analog VLSI, RF-MEMS, surface acoustic wave resonators, and oscillators in particular. She is currently a visiting scholar at the Biosensors and Bioelectronics Center, Linköping University, Sweden.

8.3 Electrochemical Biosensors 293

8.4 Acoustic Wave-based Mass Sensors 297

8.5 Bulk Acoustic Wave Sensors 297

8.6 Surface Acoustic Wave Mass Sensors 300

8.7 Conclusion and Future Prospects 302

References 303

9 Polymer MEMS Sensors 305
V. Seena, Prasenjithn Ray, Prashanthi Kovur, Manoj Kandpal and V. Ramgopal Rao

9.1 Introduction 306

9.2 Polymer Nanocomposite Piezoresistive Microcantilever Sensors 309

9.3 Organic CantiFET 318

9.4 Polymer Microcantilever Sensors with Embedded Al-doped ZnO Transistor 324

9.5 Piezoelectric Nanocomposite (SU-8/ZNO) Thin Films Studies and Their Integration with Piezoelectric MEMS Devices 327

9.6 Polymer Nanomechanical Cantilever Sensors for Detection of Explosives 334

References 337

10 Assembly of Polymers/Metal Nanoparticles and their Applications as Medical Devices 343
Magdalena Stevanovic

10.1 Introduction 344

10.2 Platinum Nanoparticles 346

10.3 Gold Nanoparticles 347

10.4 Silver Nanoparticles 350

10.5 Assembly of Polymers/Silver Nanoparticles 351

10.6 Conclusion 357

Acknowledgements 357

References 357

11 Combination of Molecular Imprinting and Nanotechnology: Beginning of a New Horizon 367
Rashmi Madhuri, Ekta Roy, Kritika Gupta and Prashant K. Sharma

11.1 Introduction 368

11.2 Classification of Imprinted Nanomaterials 374

11.3 Imprinted Materials at Nanoscale 412

11.4 Conclusions & Future Outlook 418

Acknowledgements 419

References 419

12 Prussian Blue and Analogues: Biosensing Applications in Health Care 423
Salazar P, Martin M, O’Neill RD, Lorenzo-Luis P, Roche R and González-Mora JL

12.1 Introduction 424

12.2 General Aspects of Prussian Blue and Other Hexacyanoferrates 426

12.3 Prussian Blue: Hydrogen Peroxide Electrocatalysis 428

12.4 Prussian Blue: Biosensor Applications 430

12.5 Prussian Blue: Immunosensor Applications 439

12.6 Conclusions 446

Acknowledgment 446

References 447

13 Efficiency of Biosensors as New Generation of Analytical Approaches at the Biochemical Diagnostics
of Diseases 451
N.F. Starodub and M. D. Melnychuk

13.1 Introduction 452

13.2 General Approaches for the Development of Optical Immune Biosensors 452

13.3 Electrochemical Enzymatic Biosensors Based on the Ion-sensitive Field Effect Transistors (ISFETs) 471

13.4 Multi-parametrical Biosensors [49-51] 475

13.5 Modeling Selective Sites and their Application in the Sensory Technology 478

13.6 Conclusion 481

References 482

14 Nanoparticles: Scope in Drug Delivery 487
Megha Tanwar, Jaishree Meena and Laxman S. Meena

14.1 Introduction 488

14.2 Different Forms of Nanoparticles as Drug Delivery 489

14.3 Tuberculosis Targeting Nanoparticles 493

14.4 Cancer & Tumor Targeting Nanoparticles 505

14.5 Conclusion 511

References 512

15 Smart Polypeptide Nanocarriers for Malignancy Therapeutics 523
Jianxun Ding, Di Li, Xiuli Zhuang and Xuesi Chen

15.1 Introduction 523

15.2 Smart Polypeptide Nanovehicles for Antitumor Drug Delivery 525

15.3 Conclusions and Perspectives 539

References 539

Index 547

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