Local Therapies for Glioma

by Westphal, Manfred; Tonn, Christian; Ram, Zvi

ISBN13:
9783211403556
ISBN10:
3211403558
Format: Hardcover
Copyright: 2003-10-01
Publisher: Springer Verlag
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Local Therapies for Glioma > ISBN13: 9783211403556

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Summary

In addition to surgery and radiotherapy, local treatment modalities for the management of brain tumours are increasingly being developed and clinically tested. This book describes for the first time basic tumour biology as well as all current procedures in progress at the most recent level of knowledge, presented by leading experts in the respective fields. Image guided resection procedures, fluorescence guided surgery, developments in interstitial radiosurgery are addressed, just as intracavitary chemotherapy and all current concepts and studies of interstitial targeted therapy. Owing to its topicality this book will remain for long the standard for this comprehensively treated subject.

Editors' remarks: Evolving concepts for local therapies for glioma	p. VII
Intraoperative imaging--MRI	p. 1
Stereotactic volumetric resection of gliomas	p. 5
Fluorescence-guided resections of malignant gliomas--an overview	p. 9
Postoperative imaging after brain tumor resection	p. 13
Preliminary experience in glioma surgery with intraoperative high-field MRI	p. 21
Awake craniotomy in glioma surgery	p. 31
External beam and conformal radiotherapy in the management of gliomas	p. 37
Interstitial stereotactic radiosurgery	p. 45
Implantable drug-releasing biodegradable microspheres for local treatment of brain glioma	p. 51
Non-invasive transcranial High Intensity Focused Ultrasound (HIFUS) under MRI thermometry and guidance in the treatment of brain lesions	p. 57
Intracavitary chemotherapy for glioblastoma: present status and future directions	p. 61
Intralesional radioimmunotherapy in the treatment of malignant glioma: clinical and experimental findings	p. 69
Intracavitary treatment of malignant gliomas: radioimmunotherapy targeting fibronectin	p. 77
Comparing monoclonal antibodies and small peptidic hormones for local targeting of malignant gliomas	p. 83
Local convection enhanced delivery of IL4-Pseudomonas exotoxin (NBI-3001) for treatment of patients with recurrent malignant glioma	p. 93
Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studies	p. 105
Oncolytic viruses for treatment of malignant brain tumours	p. 113
Gene therapy of gliomas	p. 125
Cell therapy using encapsulated cells producing endostatin	p. 137
Stem cells in neuro-oncology--development, regeneration and treatment	p. 143
Glioma invasion--Pattern of dissemination by mechanisms of invasion and surgical intervention, pattern of gene expression and its regulatory control by tumorsuppressor p53 and proto-oncogene ETS-1	p. 153
Mechanisms of glioma cell invasion	p. 163
Invasion as limitation to anti-angiogenic glioma therapy	p. 169
Author Index	p. 179
Index of Keywords	p. 181
Table of Contents provided by Ingram. All Rights Reserved.

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