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9781441966025

Hereditary Colorectal Cancer

by ; ; ; ;
  • ISBN13:

    9781441966025

  • ISBN10:

    1441966021

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2010-10-07
  • Publisher: Springer Verlag
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Supplemental Materials

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Summary

Early detection of colorectal cancers is a significant and relatively recent achievement. Persons who carry genetic mutations linked to hereditary colorectal cancer make up 20% of the patient population. With the advent of molecular genetics and the description of hereditary colorectal cancer syndromes, clinicians and genetic counselors are able to use genetic predisposition testing as an effective and important way to identify patients and families affected by inherited colorectal cancer syndromes.

Table of Contents

History
History: Familial Adenomatous Polyposisp. 3
Historical Aspects of Lynch Syndromep. 15
Basic Sciences and Genetics
Molecular Genetics of Familial Adenomatous Polyposisp. 45
DNA Mismatch Repairp. 67
Basic Sciences and Genetics: Hamartomatous Polyposisp. 87
Hyperplastic Polyposis Syndrome: Colorectal Cancer Predispositionp. 111
MUTYH-Associated Polyposisp. 133
Polymorphic Variation and Risk of Colorectal Cancerp. 147
Pathology
The Pathologist and the Phenotype of Hereditary Colorectal Cancerp. 175
Clinical Science: Familial Adenomatous Polyposis
Genotype Phenotype Correlation in Familial Adenomatous Polyposisp. 197
Surgery for Familial Adenomatous Polyposisp. 203
Duodenal Adenomas in Familial Adenomatous Polyposisp. 219
FAP-Associated Desmoid Tumoursp. 239
Attenuated Familial Adenomatous Polyposis: Diagnosis, Management, and Future Prognosisp. 253
Clinical Science: Hereditary Nonpolyposis Colorectal Cancer
An Overview of the Lynch Syndrome (Hereditary Non-polyposis Colorectal Cancer)p. 271
Surgical Management in Lynch Syndromep. 301
Extracolonic Tumorsp. 311
Surveillancep. 335
Clinical Science: MYH Associated Polyposis
MUTYH-Associated Polyposisp. 349
Clinical Science: Hamartomatous Polyposis
Peutz-Jeghers Syndromep. 365
Clinical Aspects of Juvenile Polyposisp. 375
Hereditary Mixed Polyposis Syndrome and Multiple Adenoma Patientsp. 401
Clinical Science: Hyperplastics Polyposis
Hyperplastic Polyposisp. 411
Genetic Counseling
Genetic Counseling Overviewp. 425
Across Culture and Health Systems: Europep. 431
Across Culture and Health Systems: Asia (Hong Kong)p. 445
Across Culture and Health Systems: Asia (Japan)p. 461
Across Culture and Health Systems: Africap. 471
Across Culture and Health Systems: Argentinap. 487
Genetic Counselling Across Culture and Health Systems: Australiap. 503
Across Culture and Health Systems: Koreap. 535
Across Culture and Health Systems: Americap. 545
Psychosocial Aspects of Hereditary Colorectal Cancer
Psychological Impact of Genetic Counseling and Testing for Hereditary Colorectal Cancersp. 559
Chemoprevention
Chemoprevention for Inherited Colorectal Cancerp. 577
Registries
Registriesp. 595
Indexp. 613
Table of Contents provided by Ingram. All Rights Reserved.

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