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9780841235281

Therapeutic Protein and Peptide Formulation and Delivery

by ; ; ; ;
  • ISBN13:

    9780841235281

  • ISBN10:

    0841235287

  • Format: Hardcover
  • Copyright: 1997-08-01
  • Publisher: American Chemical Society
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Summary

This volume reviews protein stability and the analytical and biophysical characterization of proteins. It emphasizes drug delivery approaches, especially local delivery through the skin. Including both academic and industrial perspectives from such companies as Genentech, Amgen, and Merck, the book also discusses novel drug delivery polymers and the development of pharmaceutical protein formulations.

Table of Contents

Preface ix
1. Developing Pharmaceutical Protein Formulations: Assumptions and Analytical Tools
1(28)
Zahra Shahrokh
2. The Pharmaceutical Development of Insulin: Historical Perspectives and Future Directions
29(38)
Henry R. Costantino
Stanley Liauw
Samir Mitragotri
Robert Langer
Alexander M. Klibanov
Victoria Sluzky
3. Stability of the Dipeptide Aspartame in Solids and Solutions
67(12)
Leonard N. Bell
4. Mechanisms of Methionine Oxidation in Peptides
79(11)
Christian Schoneich
Fang Zhao
Jian Yang
Brian L. Miller
5. A Discussion of Limitations on the Use of Polymers for Stabilization of Proteins During the Freezing Portion of Lyophilization
90(19)
David M. Barbieri
Martin C. Heller
Theodore W. Randolph
John F. Carpenter
6. Phase Separation and Crystallization of Components in Frozen Solutions: Effect of Molecular Compatibility Between Solutes
109(10)
Ken-ichi Izutsu
Sumie Yoshioka
Shigeo Kojima
7. In Situ Formation of Polymer Matrices for Localized Drug Delivery
119(5)
Jennifer L. West
8. Transdermal Delivery of Macromolecules: Recent Advances by Modification of Skin's Barrier Properties
124(30)
Mark R. Prausnitz
9. Amino Acid Derived Polymers for Use in Controlled Delivery Systems of Peptides
154(14)
S. Brocchini
D.M. Schachter
J. Kohn
10. Analysis of the Solution Behavior of Protein Pharmaceuticals by Laser Light Scattering Photometry
168(18)
Gay-May Wu
David Hummel
Alan Herman
11. Applications of Ultraviolet Absorption Spectroscopy to the Analysis of Biopharmaceuticals
186(20)
Henryk Mach
Gautam Sanyal
David B. Volkin
C. Russell Middaugh
12. Surfactant-Stabilized Protein Formulations: A Review of Protein-Surfactant Interactions and Novel Analytical Methodologies
206(17)
LaToya S. Jones
Narendra B. Bam
Theodore W. Randolph
Author Index 223(1)
Affiliation Index 223(1)
Subject Index 223

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