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9781555810986

The DNA Provirus

by ; ; ;
  • ISBN13:

    9781555810986

  • ISBN10:

    1555810985

  • Format: Hardcover
  • Copyright: 1995-07-01
  • Publisher: Amer Society for Microbiology

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Summary

Howard Temin's pioneering scientific achievements in elucidating the fundamentals of retroviruses laid the ground work for our present understanding of the molecular basis of both cancer and HIV. Few advances in contemporary molecular biology have been as significant or as controversial as Temin's initial proposal of the provirus hypothesis, which turned molecular biology's central dogma on its head. This book focuses on the significance of temin's science as well as on current areas of research which have been profoundly affected by his discoveries.

Table of Contents

Selected papers of Howard M Temin
Reprint of Temin and Rubin's 1958 paper describing the focus assay for transformation Rous Sarcoma virus
Reprint of Temin's 1964 paper proposing the DNA provirus hypothesis
Reprint of Boettiger and Temin's 1970 paper on inactivation of BUdR-containing proviral DNA by visible light
Reprint of Temin and Mizutani's 1970 paper reporting the discovery of reverse transcriptase
Reprint of Temin's 1971 paper proposing the protovirus hypothesis
Cancer
On the origin of oncogenes
Viruses, genes and cancer: a lineage of discovery
Mammaliam development and human cancer: from the phage group to the genetics of intestinal cancer
Malignant transformation of cells by the v-Rel oncoprotein
Progress in the molecular medicine of cancer
Virology
Reprint of Shimotohno, Mizutani and Temin's 1980 paper on the similarity of the structure of retroviral proviruses to that of transposable elements
Beyond the provirus: from Howard Temin's insights on Rous Sarcoma virus to the study of Eppstein-Barr virus, the prototypic human tumor virus
Under the influence: from the provirus hypothesis to multistep carcinogenesis
Herpes simplex virus DNA replication and genome maturation
Reprint of Temin's 1993 paper on the inherent contributions of reverse transcription to retroviral variation
Retrovirus variation and evolution
HIV, AIDS and the immune system
Human retroviruses in the second decade: some pathogenic mechanisms and approaches to their control
Cherish an idea that does not attach itself to anything; Gene therapy in CD4+ T lymphocytes in SCID-hu mice
The dilemma of developing and testing AIDS vaccines;reprint of temin's 1993 paper proposing a new approach to develop a human immunodeficiency virus vaccine
Table of Contents provided by Publisher. All Rights Reserved.

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