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9780124507401

Clinical Impact of Bone and Connective Tissue Markers

by ;
  • ISBN13:

    9780124507401

  • ISBN10:

    0124507409

  • Format: Hardcover
  • Copyright: 1989-07-01
  • Publisher: Academic Pr

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Supplemental Materials

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Summary

For many years, biochemical tests have been widely used for the diagnosis, classification, and monitoring of bone and connective tissue disease. However, shortcomings in terms of the specificity and sensitivity of such tests have prompted continual questioning about their clinical usefulness. This book, based on a meeting organized jointly by the University of Uppsala and Pharmacia Diagnostics AB, reviews our current understanding of basic bone and connective tissue biochemistry and the clinical role of biochemical markers specific to related diseases, with special reference to rheumatoid arthritis and osteoporosis.

Table of Contents

Connective Tissue Components and Turnover: The Collagens
Basement Membranes
Versatility of Cell Adhesion Mechanisms
Proteoglycans and Matrix Proteins of Connective Tissue with Special Reference to Cartilage
Hyaluronan: Sources, Turnover, and Metabolism
Catabolism in Liver Sinusoids
Interactions between the Immune System and Connective Tissue in Arthritis: Aspects on Connective Tissue Proliferation and Breakdown
Bone Components and Turnover: Biochemistry of the Bone Matrix
Non-Collagenous Proteins of Bone
Differentiation and Function of Cells of Osteoblastic Lineage
Osteoblast Phenotypic Expression and Bone Markers
Gene Expression and Functional Studies of the Vitamin K-Dependent Protein of Bone, Osteocalcin
Mechanism of Calcification in Bone: Role of Collagen Fibrils and Collagen-Phosphoprotein Complexes in Vitro and in Vivo
The Possible Roles of Cytokines in Bone and Cartilage Metabolism
Clinical Applications of Connective Tissue Markers: Markers of Collagen Assembly and Turnover
Collagen Markers in Clinical Work
Molecular Markers for Joint Disease
Keratan Sulfate as a Marker for Cartilage Proteoglycan Catabolism
Hyaluronan as a Clinical Marker
Immunity to Cartilage Components and the Development of Chronic Inflammatory Arthritis
Round Table Discussion: Present
Table of Contents provided by Publisher. All Rights Reserved.

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