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9780195042672

Epinephrine in the Central Nervous System

by ; ;
  • ISBN13:

    9780195042672

  • ISBN10:

    0195042670

  • Format: Hardcover
  • Copyright: 1988-03-24
  • Publisher: Oxford University Press
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Summary

Long thought to be unimportant in central nervous system activity, epinephrine is now known to play a key role in the brain's regulation of blood pressure, cardiovascular function, and other autonomic activities. This encyclopedic volume, written by leading international researchers, offers a comprehensive account of the chemical neuroanatomy, genetics, chemistry, and pharmacology of CNS epinephrine and its effects on behavior and autonomic function.

Table of Contents

Historical Overview
Following the Trail of Epinephrine from the Periphery to the Brain
The Changing Face of Research on Epinephrine
Morphology of Brain Epinephrine Systems
Central Phenylethanolamine N-Methyltransferase-Immunoreactive Neurons: Distribution, Projections, Fine Structure, Ontogeny and Coexisting Peptides
Morphometric Studies of Epinephrine and Neuropeptide Y (NPY) Costoring Neurons in the Rat Brain
Mapping the Alpha Adrenergic Receptor in the Central Nervous System: A Guide to Structure and Function
Connectivity and Ultrastructure of Nonadrenergic and Adrenergic Neurons in the Medulla Oblongata
Regulation and Genetics of Adrenergic Systems
Inheritance of Epinephrine Formation Rates and Phenylethanolamine N-Methyltransferase Structural Heterology in Inbred Rat Strains
Molecular Basis for the Difference in Buffalo and Fischer Rat PNMT Expression
Steroid Control of Neurotransmitter Synthesis: Glucocorticoid Regulation of Phenylethanolamine N-Methyltransferase
Brain Epinephrine in Hypertension and Stress
Pharmacological Approaches to Adrenergic Systems
Approaches to the Design of Selective Inhibitors of Phenylethanolamine N-Methyltransferase (PNMT): Development of an Active Site Model for PNMT
Biochemical Pharmacology of Brain Epinephrine Neurons: Comparison with Nonephinephrine Neurons
Regulation of Anterior Pituitary Hormone Secretion by Brain Epinephrine
Epinephrine and CRF Stimulate ACTH Release and Proopiomelanocortin Gene Expression
Central Epinephrine Neurons and Alpha-2 Adrenoceptors
Modulation of Epinephrine Release from Adrenal Medulla by Gamma-Aminobutyric Acid
Brain and Peripheral Adrenoceptors
Subtypes of Alpha-2 Adrenoceptors in Human and Rat Brain
Agonist-Regulated Metabolism of Alpha- and Beta-Adrenoceptors
Functional Association Between Epinephrine Neurons and Alpha-2 Adrenoceptors in Discrete Brain Areas: Analysis in Inbred Rat Strains
Regulation of Brain Stem and Platelet Alpha-2 Adrenoceptors
The Beta-Adrenergic Receptor-Coupled Adenylate Cyclase System
Modification of Guanine Nucleotide Actions on Receptors and Adenylate Cyclase
Central and Peripheral Alpha-2 and Beta Adrenoceptor Changes Induced by Antidepressant Treatments
Adrenergic Neuron Electrophysiology and Behavior
Inhibitory Synaptic Transmission Mediated by Catecholamines
Bulbospinal Epinephri
Table of Contents provided by Publisher. All Rights Reserved.

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