Recent breakthroughs in the field of cell growth, particularly in the control of cell size, are reviewed by experts in the three major divisions of the field: growth of individual cells, growth of organs, and regulation of cell growth in the contexts of development and cell division. This book is an introductory overview of the field and should be adaptable as a textbook.

Preface,

vii

Foreword,

ix

Paul Nurse

1 How Metazoans Reach Their Full Size: The Natural History of Bigness,

1

(22)

P.H. O'Farrell

2 Growth and Cell Cycle Control in Drosophila,

23

(62)

B.A. Edgar and H.F. Nijhout

3 Coordination of Cell Growth and Cell-cycle Progression in Proliferating Mammalian Cells,

85

(16)

I. Conlon, A. Lloyd, and M. Raff

4 Coordination of Cell Growth and Cell Division,

101

(38)

E.V. Schmidt

5 TOR Signaling in Yeast: Temporal and Spatial Control of Cell Growth,

139

(28)

R. Loewith and M.N. Hall

6 Growth Regulation by Insulin and TOR Signaling in Drosophila,

167

(26)

S.J. Leevers and E. Hafen

7 Growth Control through the mTOR Network,

193

(42)

D.A. Guertin, D.-H. Kim, and D.M. Sabatini

8 IGF-I Receptor Signaling in Cell Growth and Proliferation,

235

(30)

R. Baserga

9 S6K Integrates Nutrient and Mitogen Signals to Control Cell Growth,

265

(34)

J. Montagne and G. Thomas

10 Translation Initiation and Cell Growth Control,

299

(30)

E. Petroulakis and N. Sonenberg

11 Forging the Factory: Ribosome Synthesis and Growth Control in Budding Yeast,

329

(42)

P. Jorgensen, M. Tyers, and J.R. Warner

12 Control of rRNA and tRNA Production Is Closely Tied to Cell Growth,

371

(42)

R.J. White

13 Autophagy: Reversing Cell Growth,

413

(18)

Y. Ohsumi

14 Synaptic Growth, Synaptic Maintenance, and the Persistence of Long-term Memory Storage,

431

(42)

C.H. Bailey, R.D. Hawkins, and E.R. Kandel

15 Control of Synaptic Function by Local Protein Synthesis and Degradation,

473

(36)

W.B. Smith, B. Bingol, G.N. Patrick, and E.M. Schuman

16 Lymphocyte Growth,

509

(20)

D.E. Bauer and C.B. Thompson

17 Modulating Skeletal Muscle Hypertrophy and Atrophy: Signaling Pathways and Therapeutic Targets,

529

(20)

D.J. Glass and G.D. Yancopoulos

18 Mechanisms Controlling Heart Growth in Mammals,

549

(56)

J.R. McMullen and S. Izumo

19 Regulation of Cell Growth in the Endocrine Pancreas,

605

(20)

K. Roovers and M.J. Birnbaum

20 Plant Cell Growth,

625

(14)

B. Menand and C. Robaglia

Index,

639

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