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Contributors xi
Editorial Preface xvii
Abbreviations xix
PART I FLUORINE-18 LABELED RADIOPHARMACEUTICALS 1
1. Synthesis of (−)-[18F]Flubatine ([18F]FLBT) 3Megan N. Stewart, Brian G. Hockley, and Peter J. H. Scott
2. Synthesis of [18F]-(−)Fluoroethoxy Benzovesamicol ([18F]FEOBV) 13Brian G. Hockley, Megan N. Stewart, and Peter J. H. Scott
3. Synthesis of [18F]Fluoromethylcholine ([18F]FCH) via [18F]Fluoromethyl Tosylate 21Melissa E. Rodnick, Allen F. Brooks, Brian G. Hockley, Bradford D. Henderson, and Peter J. H. Scott
4. Radiosynthesis of [18F]Flotegatide ([18F]RGD-K5) 29Hartmuth C. Kolb, Fanrong Mu, Umesh Gangadharmath, Vani P. Mocharla, Zhihong Zhu, Ashok Chaudhary, and Joseph C. Walsh
5. Synthesis of 3-[18F]Fluoro-5-(2-Pyridinylethynyl) Benzonitrile ([18F]FPEB) 41Steven H. Liang, Daniel L. Yokell, Raul N. Jackson, Peter A. Rice, Eli Livni, David Alagille, Gilles Tamagnan, Thomas Lee Collier, and Neil Vasdev
6. Radiosynthesis of 2′-Deoxy-2′-[18F]Fluoro-5-Methyl-1-β-d-Arabinofuranosyluracil ([18F]FMAU) 53Kai Chen and Peter S. Conti
PART II CARBON-11 LABELED RADIOPHARMACEUTICALS 63
7. Synthesis of N-[11C]Methyl-4-Piperidinyl Propionate ([11C]PMP) 65Xia Shao and Peter J. H. Scott
8. Synthesis of 1-(2,4-Dichlorophenyl)-4-Cyano-5-(4-[11C]methoxyphenyl)-N-(Piperidin-1-yl)-1H-Pyrazole-3-Carboxamide ([11C]OMAR) 73Xia Shao, Keunsam Jang, and Peter J. H. Scott
9. Synthesis of Carbon-11 Labeled (+)-4-Propyl-3,4,4a,5,6,10b-Hexahydro-2H-Naphtho[1,2-b][1,4]Oxazin-9-Ol ([11C]-(+)-PHNO) 81Christophe Plisson, Joaquim Ramada-Magalhaes, and Jan Passchier
10. Synthesis of (R)-[N-Methyl-11C]PK11195 93Vítor H. Alves, Antero J. Abrunhosa, and Miguel Castelo-Branco
PART III OTHER RADIOPHARMACEUTICALS 103
11. Synthesis of Oxygen-15 Water ([15O]H2O) 105David W. Dick and G. Leonard Watkins
PART IV NEW METHODS FOR THE SYNTHESIS AND QUALITY CONTROL OF RADIOPHARMACEUTICALS 115
12. Direct, Nucleophilic Radiosynthesis of [18F]Trifluoroethyl Tosylate 117Patrick J. Riss, Waqas Rafique, and Franklin I. Aigbirhio
13. Synthesis of [18F]N-Methyl Lansoprazole via Generation of a [18F]Trifluoromethyl Group 123Allen F. Brooks, Melissa E. Rodnick, Garret M. Carpenter, and Peter J. H. Scott
14. [18F]Fluorination of (Mesityl)(Aryl)Iodonium Salts 129Naoko Ichiishi, Allen F. Brooks, Joseph J. Topczewski, Melissa E. Rodnick, Melanie S. Sanford, and Peter J. H. Scott
15. Pd(IV)-Mediated Fluorination of Arenes with [18F]F– for PET Imaging 139Nathan J. Schauer, Stephen M. Carlin, Hong Ren, and Jacob M. Hooker
16. Silicon Fluoride Acceptors (SIFAs) for Peptide and Protein Labeling with 18F 149Ralf Schirrmacher, Alexey Kostikov, Carmen Wängler, Klaus Jurkschat, Vadim Bernard-Gauthier, Esther Schirrmacher, and Björn Wängler
17. Solid Phase Synthesis of [18F]-2-Fluoro-2-Deoxy-d-Glucose: A Resin-Linker-Vector (RLV) Approach 163Lynda J. Brown, Imtiaz Khan, Harry J. Wadsworth, Alexander Jackson, Nianchun Ma, Nicolas Millot, Sue M. Champion, Denis R. Bouvet, Alex M. Gibson, and Richard C. D. Brown
18. Production and Reaction of [11C]Carbon Disulfide for the Synthesis of [11C]Dithiocarbamates 177Philip W. Miller
19. One-Pot, Direct Incorporation of [11CO2] into Carbamates 185Christian K. Moseley and Jacob M. Hooker
20. Radiosynthesis of [11C]Carboxamides via Reaction of [11C]CO2 Captured by a Cu(I)-Based Catalyst System with Boronic Acid Ester Precursors 197Patrick J. Riss, Shuiyu Lu, Sanjay Telu, Franklin I. Aigbirhio, and Victor W. Pike
21. Ethanol as a Solvent for Carbon-11 Radiochemistry 207Xia Shao, Maria V. Fawaz, Keunsam Jang, and Peter J. H. Scott
22. Synthesis and Applications of [11C]Hydrogen Cyanide 233Xia Shao, Melissa E. Rodnick, Allen F. Brooks, and Peter J. H. Scott
23. Determination of Radiochemical Purity and Radiochemical Identity of [13N]NH3 Using Thin Layer Chromatography 241Peter A. Rice and Daniel L. Yokell
Appendix 1: Supplier Information 247
Index 253
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