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Note: Supplemental materials are not guaranteed with Rental or Used book purchases.
Purchase Benefits
What is included with this book?
NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists.
This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies.
Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes.
About eMagRes Handbooks
eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry.
Have the content of this handbook and the complete content of eMagRes at your fingertips!Visit: www.wileyonlinelibrary.com/ref/eMagRes
Jeremy R. Everett, Ph.D., Department of Pharmaceutical, Chemical & Environmental Sciences, University of Greenwich, UK
John C. Lindon, Ph.D., Imperial College London, UK
Ian D. Wilson, Ph.D., Imperial College London, UK
Robin Harris, Ph.D., Department of Chemistry, University of Durham, UK
Contributors xi
Series Preface xvii
Preface xix
Part A: Introduction 1
1 Drug Discovery and Development: The Role of NMRJeremy R. Everett 3
Part B: NMR Theory & Experimental Methods 21
2 Modern NMR Pulse Sequences in Pharmaceutical R&DJohn A. Parkinson 23
3 Experimental NMR Methods for Pharmaceutical Research and DevelopmentAnthony C. Dona 41
4 19F NMR Spectroscopy: Applications in Pharmaceutical StudiesJohn C. Lindon and Ian D. Wilson 53
5 Quantitative NMR Spectroscopy in Pharmaceutical R&DUlrike Holzgrabe 63
6 High-throughput NMR in Pharmaceutical R&DJohn C. Hollerton 79
7 Multivariate Data Analysis Methods for NMR-based Metabolic Phenotyping in Pharmaceutical and Clinical ResearchKirill A. Veselkov, James S. McKenzie, and Jeremy K. Nicholson 89
Part C: Idea to Lead 103
8 The Role of NMR in Target Identification and Validation for Pharmaceutical R&DKrishna Saxena and Harald Schwalbe 105
9 High-resolution MAS NMR of Tissues and CellsLeo L. Cheng 117
10 NMR Studies of Inborn Errors of MetabolismSarantos Kostidis and Emmanuel Mikros 131
11 NMR-based Structure Confirmation of Hits and Leads in Pharmaceutical R&DPhilip J. Sidebottom 147
12 Fragment-based Drug Design Using NMR MethodsLeonor Puchades-Carrasco and Antonio Pineda-Lucena 155
13 Hit Discovery from Natural Products in Pharmaceutical R&DOlivia Corcoran 173
Part D: Lead to Drug Candidate 183
14 NMR-based Structure Determination of Drug Leads and CandidatesTorren M. Peakman 185
15 Mixture Analysis in Pharmaceutical R&D Using Hyphenated NMR TechniquesIan D. Wilson and John C. Lindon 197
16 Conformation and Stereochemical Analysis of Drug MoleculesGary J. Sharman 207
17 NMR Methods for the Assignment of Absolute Stereochemistry of Bioactive CompoundsJose M. Seco and Ricardo Riguera 221
18 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and SafetyThomas M. Bocan, Lauren Keith, and David M. Thomasson 255
19 Practical Applications of NMR Spectroscopy in Preclinical Drug Metabolism StudiesRaman Sharma and Gregory S. Walker 267
20 Preclinical Drug Efficacy and Safety Using NMR SpectroscopyMuireann Coen and Ian D. Wilson 281
21 Characterization of Pharmaceutical Compounds by Solid-state NMRFrederick G. Vogt 297
22 Structure-based Drug Design Using NMRMark Jeeves, Lee Quill, and Michael Overduin 317
23 Pharmaceutical Technology Studied by MRIDavid G. Reid and Stephen J. Byard 331
Part E: Clinical Development 345
24 NMR-based Metabolic Phenotyping for Disease Diagnosis and StratificationBeatriz Jiménez 347
25 NMR-based Pharmacometabonomics: A New Approach to Personalized MedicineJeremy R. Everett 359
26 Clinical MRI Studies of Drug Efficacy and SafetyDavid G. Reid, Paul D. Hockings, and Nadeem Saeed 373
27 The Role of NMR in the Protection of Intellectual Property in Pharmaceutical R&DFrederick G. Vogt 385
Part F: Drug Manufacture 395
28 Analysis of Counterfeit Medicines and Adulterated Dietary Supplements by NMRMyriam Malet-Martino and Robert Martino 397
29 Pharmaceutical Industry: Regulatory Control and Impact on NMR SpectroscopyAndrea Ruggiero and Sarah K. Branch 413
30 NMR Spectroscopy in the European and US PharmacopeiasHelen Corns and Sarah K. Branch 425
31 NMR in Pharmaceutical ManufacturingEdwin Kellenbach and Paulo Dani 441
Index 453
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