Thrombopoiesis and Thrombopoietins

by Kuter, David J.; Hunt, Pamela; Sheridan, William; Zucker-Franklin, Dorothea

• ISBN13: 9780896033795
• ISBN10: 0896033791
• Format: Hardcover
• Copyright: 1997-01-01
• Publisher: Humana Pr Inc

Summary

David Kuter and a host of leading international researchers summarize in one volume all the knowledge of thrombopoietins (TPO) available today. The distinguished experts review the history of the search to discover TPO, describe the molecular and biological characteristics of this new molecule, and present the results of the preclinical animal experiments that will guide clinical use of this new hormone. Along the way they provide the most recent and comprehensive guide to the biology of megakaryocytes and platelets.

Table of Contents

Foreword	v	(8)
Shirley Ebbe
Preface	xiii	(4)
List of Contributors	xvii
PART I: INTRODUCTION	3	(92)
1 Megakaryocyte Biology	3	(38)
Carl W. Jackson
Julie T. Arnold
Tamara I. Pestina
Paula E. Stenberg
2 Platelet Structure and Function	41	(22)
Dorothea Zucker-Franklin
3 The Evolution of Mammalian Platelets	63	(16)
Jack Levin
4 Potential Clinical Applications of Thrombopoietic Growth Factors	79	(16)
Charles A. Schiffer
PART II: THE SEARCH FOR THE PHYSIOLOGIC REGULATOR OF PLATELET PRODUCTION	95	(86)
5 Historical Perspective and Overview	95	(14)
Eric M. Mazur
6 The Murine Myeloproliferative Leukemia Virus MPLV, v-mpl Oncogene, and c-mpl	109	(14)
Francoise Wendling
Sylvie Gisselbrecht
7 Mpl Expression and Functional Role in Human Megakaryocytopoiesis	123	(12)
Francoise Wendling
Najet Debili
William Vainchenker
8 The Purification and Cloning of Human Thrombopoietin	135	(8)
Dan Eaton
9 The Purification of Thrombopoietin from Thrombocytopenic Plasma	143	(22)
David J. Kuter
Hiroshi Miyazaki
Takashi Kato
10 The Role of Other Hemopoietic Growth Factors and the Marrow Microenvironment in Megakaryocytopoiesis	165	(16)
Ronald Hoffman
PART III: MOLECULAR BIOLOGY	181	(36)
11 Structure of Thrombopoietin and the Thrombopoietin Gene	181	(8)
Austin L. Gurney
Frederic J. de Sauvage
12 Transcription Factors in Megakaryocyte Differentiation and Gene Expression	189	(14)
Ramesh A. Shivdasani
13 The Biological Significance of Truncated and Full-Length Forms of Mpl Ligands	203	(14)
Donald Foster
Pamela Hunt
PART IV: CELLULAR BIOLOGY	217	(84)
14 In Vitro Effects of Mpl Ligand on Human Hemopoietic Progenitor Cells	217	(20)
Najet Debili
Elisabeth Cramer
Francoise Wendling
William Vainchenker
15 Effect of Cytokines on the Development of Megakaryocytes and Platelets: An Ultrastructural Analysis	237	(20)
Dorothea Zucker-Franklin
16 The Thrombopoietin Receptor, Mpl, and Signal Transduction	257	(14)
Kenneth Kaushansky
Virginia C. Broudy
Jonathan G. Drachman
17 Regulation of Proplatelet and Platelet Formation In Vitro	271	(14)
Esther Choi
In Vitro Effects of Mpl Ligands on Platelet Function	285	(16)
Laurence A. Harker
Ulla M. Marzec
Christopher F. Toombs
PART V: PRECLINICAL BIOLOGY	301	(58)
19 In Vivo Dose-Response Effects of Mpl Ligands on Platelet Production and Function	301	(20)
Laurence A. Harker
Christopher F. Toombs
Richard B. Stead
20 Efficacy of Mpl Ligands and other Thrombopoietic Cytokines in Animal Models	321	(28)
Ann M. Farese
Thomas J. MacVittie
21 Genetic Manipulation of Mpl Ligand and Thrombopoietin In Vivo	349	(10)
Frederic J. de Sauvage
Mark W. Moore
PART VI: CLINICAL BIOLOGY	359	(38)
22 Serum Levels of Thrombopoietin in Health and Disease	359	(18)
Janet Lee Nichol
23 The Regulation of Platelet Production In Vivo	377	(20)
David J. Kuter
Glossary	397	(4)
Index	401