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9781850704973

Pharmacology : Drug Actions and Reactions

by ; ;
  • ISBN13:

    9781850704973

  • ISBN10:

    185070497X

  • Edition: 6th
  • Format: Paperback
  • Copyright: 2000-06-01
  • Publisher: Taylor & Francis
  • View Upgraded Edition

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Supplemental Materials

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Summary

This is an updated, expanded new edition of Dr. Ruth Levine's renowned Pharmacology: Drug Actions and Reactions. It covers basic pharmacological principles and the general concepts of chemical-biological interactions and now includes important new material on molecular biology, updated clinical information, and added coverage of the newer drugs. For the sixth edition of this landmark book Dr. Levine is joined by co-authors Dr. Carol T. Walsh and Dr. Rochelle D. Schwartz-Bloom. Acclaimed for its exceptionally thorough coverage, superb presentation, and intelligent organization, the book guides you through the most elementary aspects of pharmacology to a sophisticated understanding of drug mechanisms. Each chapter contains a series of thought-provoking essay-type questions designed to test comprehension of the material in the chapter. In addition, a sufficient number of important, specific examples are included to illustrate the application of the principles. With the background provided by Pharmacology: Drug Actions and Reactions, Sixth Edition, you will be prepared to understand the actions of most individual drugs.

Table of Contents

Foreword to the First Edition vii
Byron B. Clark
Preface to the Sixth Edition ix
Preface to the First Edition xi
The Heritage of Pharmacology
1(16)
The Beginnings
1(8)
The Rise of Pharmacology
9(6)
Synopsis
15(1)
Guides for Study and Review
16(1)
Suggested Reading
16(1)
The Scope of Pharmacology
17(10)
Drug Nomenclature
19(2)
Sources of Information about Drugs
21(4)
Guides for Study and Review
25(2)
How Drugs Act on The Living Organism
27(296)
Site of Action
31(3)
Mechanism of Action
34(13)
Synopsis
47(1)
Guides for Study and Review
48(1)
Suggested Reading
48(4)
How Drugs Reach Their Site of Action
General Principles of Passage of Drugs Across Biologic Barriers
51(1)
Passive Diffusion
52(14)
Specialized Transport Processes
66(5)
Filtration
71(1)
Synopsis
71(2)
Guides for Study and Review
73(1)
Suggested Reading
74(2)
How Drugs Reach Their Site of Action
Absorption
75(1)
Routes of Administration
76(3)
Absorption from the Gastrointestinal Tract
79(13)
Absorption through the Skin
92(4)
Absorption from the Respiratory Tract
96(3)
Absorption from Subcutaneous Sites
99(3)
Absorption from Intramuscular Sites
102(1)
Intravenous Administration
102(1)
General Considerations
103(2)
Guides for Study and Review
105(1)
Suggested Reading
106(1)
How Drugs Reach Their Site of Action
Distribution
107(1)
Capillary Permeability
107(2)
Magnitude of Distribution
109(3)
Binding of Drugs of Plasma Proteins and Other Tissue Components
112(2)
Distribution from Blood to Brain
114(4)
Distribution from Mother to Fetus
118(2)
Remarks
120(1)
Guides for Study and Review
121(1)
Suggested Reading
121(3)
How the Actions of Drugs are Terminated
Excretion
123(1)
Routes of Excretion
124(23)
Excretion of drugs by the Kidney
125(20)
Excretion of drugs by the liver
145(2)
Synopsis
147(1)
Guides for Study and Review
147(2)
Suggested Reading
149(2)
How the Actions of Drugs are Terminated
Biotransformation
151(1)
The Mediators of Biotransformation
151(5)
Chemical Pathways of Biotransformation
156(15)
Factors Affecting Drug Biotransformation
171(7)
Synopsis
178(1)
Guides for Study and Review
179(1)
Suggested Reading
179(3)
General Principles of the Quantitative Aspects of Drug Action
Dose-Response Relationships
181(1)
Quantitative Aspects of Drug-Receptor Interactions
182(14)
The Quantal Dose-Response Relationship
196(12)
The Selectivity of Drug Action
208(3)
Synopsis
211(4)
Guides for Study and Review
215(1)
Suggested Reading
216(7)
General Principles of the Quantitative Aspects of Drug Action
Time-Response Relationships
219(4)
Rate of Drug Absorption
223(3)
Rate of Drug Elimination
226(13)
The Time Course of Drug Action after Single Doses
239(5)
The Kinetics of Drug Accumulation following Multiple Doses
244(9)
Synopsis
253(2)
Guides for Study and Review
255(2)
Suggested Reading
257(3)
Factors Modifying the Effects of Drugs in Individuals
Variability in Response Attributable to the Biologic System
259(1)
Body Weight and Size
260(1)
Age
260(5)
Gender
265(1)
Genetic Factors
266(14)
General Conditions of Health
280(1)
Psychologic Factors: The Placebo Effect
281(2)
Remarks
283(1)
Guides for Study and Review
283(1)
Suggested Reading
284(3)
Factors Modifying the Effects of Drugs in Individuals
Variability in Response Attributeable to the Conditions of Administration
287(1)
Modified Drug Effects after Repeated Administration of a Single Drug
287(18)
Drug Interactions
305(10)
Synopsis
315(5)
Guides for Study and Review
320(1)
Suggested Reading
321(2)
Drug Toxicity
323(44)
Classifications of Toxic Reactions
325(8)
Evaluation of Drug Toxicity
333(12)
Incidence of Poisoning
345(8)
Treatment of Toxicity
353(10)
Synopsis
363(1)
Guides for Study and Review
364(2)
Suggested Reading
366(1)
How Drugs Alter Physiologic Function: A Recapitulation
367(22)
Drug Actions Influencing the Fundamental Properties Common to all Cells
368(1)
Drug Actions Influencing the Autonomic Nervous System
369(17)
Guides for Study and Review
386(1)
Suggested Reading
387(2)
The Pharmacologic Aspects of Drug Abuse and Drug Dependence
389(36)
The Functional Organization of the Central Nervous System
390(7)
General Characteristics of Drug Dependence
397(3)
General Depressants of the Central Nervous System
400(3)
Narcotic Analgesics
403(4)
Stimulants of the Central Nervous System
407(4)
Psychedelics (Hallucinogens)
411(6)
Drug-Seeking Behavior and the Reward Pathway
417(1)
Drugs Used to Treat Drug Dependence
418(1)
Synopsis
419(2)
Guides for Study and Review
421(2)
Suggested Reading
423(2)
The Development and Evaluation of New Drugs
425(28)
Development and Evaluation in the Laboratory
425(12)
Clinical Studies
437(9)
The New Drug Application (NDA)
446(4)
Concluding Remarks
450(1)
Guides for Study and Review
450(1)
Suggested Reading
451(2)
Glossary 453(92)
APPENDIXES
1. Drugs Affecting the Gastrointestinal Tract
475(10)
2. Drugs Influencing Renal Function
485(6)
3. Chemotherapy
491(12)
4. Drugs Used to Alter the Perception of and Response to Pain
503(18)
5. Sedatives and Hypnotics
521(6)
6. Drugs Used in the Treatment of Psychiatric Disorders
527(8)
7. Central Nervous System Stimulants
535(6)
8. Weights and Measures
541(4)
Index 545

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